Frontier View on Nanotechnological Strategies for Neuro-therapy

Curr Drug Metab. 2018;19(7):596-604. doi: 10.2174/1389200219666180305144143.


Background: Nanotechnology exploits materials and devices with a functional organization that has been engineered at the nanometre scale. The application of nanotechnology in neuroscience involves specific interactions with neurons and glial cells. This property is used for delivering drugs and other small molecules (such as genes, oligonucleotides and contrasting agents) across the blood brain barrier (BBB), an important requirement for delivering the drug successfully to the brain.

Objective: Nanotechnology based approaches (NBA) favours transcytosis-mediated delivery of nanoparticles to the brain by crossing the BBB. The last five years have witnessed the successful applications of NBA to treat neurological disorders. It is expected that the development of novel NBA will result in important insights on the brain mechanisms, and eventually provide better medical care to patients suffering from neurological disorders.

Conclusion: This review introduces the emerging work in this area and summarizes the successful NBA used in recent past for treating various neurological disorders ike Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, meningitis and glioblastoma.

Keywords: Alzheimer's disease; blood brain barrier; drug delivery; nanotechnology; nanotechnology based approaches; neurological disorders..

Publication types

  • Review

MeSH terms

  • Animals
  • Brain / metabolism
  • Humans
  • Nanoparticles / therapeutic use*
  • Nanotechnology
  • Neurodegenerative Diseases / drug therapy*
  • Transcytosis