Serum steroid hormone profiles in postmenopausal smokers and nonsmokers

Fertil Steril. 1987 Mar;47(3):398-401.

Abstract

Morning serum steroid levels were determined in postmenopausal chronic smokers and nonsmokers. Postmenopausal smokers (n = 9) had significantly elevated levels of cortisol, progesterone (P), 17-hydroxyprogesterone (17-OHP), androstenedione, and testosterone compared with nonsmokers (n = 16). The increases were most significant for cortisol (P less than 0.001) and 17-OHP (P less than 0.0005). Estrone, estradiol, dihydrotestosterone, and dehydroepiandrosterone sulfate did not differ between the groups. P to estrogen ratios tended to be higher in the smoking population. The significantly elevated P levels observed in the group of postmenopausal smokers may explain, in part, the epidemiologic finding that women smokers have a decreased incidence of endometrial carcinoma. In addition, the hypercortisolism associated with smoking may increase the risk of osteoporosis.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 17-alpha-Hydroxyprogesterone
  • Androstenedione / blood
  • Dehydroepiandrosterone / analogs & derivatives
  • Dehydroepiandrosterone / blood
  • Dehydroepiandrosterone Sulfate
  • Dihydrotestosterone / blood
  • Estradiol / blood
  • Estrone / blood
  • Female
  • Humans
  • Hydrocortisone / blood
  • Hydroxyprogesterones / blood
  • Menopause*
  • Middle Aged
  • Progesterone / blood
  • Smoking*
  • Steroids / blood*
  • Testosterone / blood

Substances

  • Hydroxyprogesterones
  • Steroids
  • Dihydrotestosterone
  • Estrone
  • Testosterone
  • Androstenedione
  • Dehydroepiandrosterone
  • Progesterone
  • Estradiol
  • Dehydroepiandrosterone Sulfate
  • 17-alpha-Hydroxyprogesterone
  • Hydrocortisone