Unique chemistry of non-heme iron enzymes in fungal biosynthetic pathways

Nat Prod Rep. 2018 Jul 18;35(7):633-645. doi: 10.1039/c7np00055c.

Abstract

Covering: up to 2018 Non-heme iron enzymes are a versatile family of oxygenases that catalyze remarkable types of chemistry. This review highlights the intriguing chemistry of non-heme iron enzymes, especially those utilizing α-ketoglutarate (α-KG) as a co-substrate, in fungal secondary metabolism and aims to summarize how nature diversifies and complexifies natural products.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Catalysis
  • Ergot Alkaloids / biosynthesis
  • Fungal Proteins / chemistry*
  • Fungal Proteins / metabolism
  • Heme
  • Hydroxyquinolines / metabolism
  • Indoles / metabolism
  • Iron
  • Ketoglutaric Acids / metabolism
  • Oxygenases / chemistry*
  • Oxygenases / metabolism*
  • Tropolone / metabolism
  • beta-Lactams / metabolism

Substances

  • Ergot Alkaloids
  • Fungal Proteins
  • Hydroxyquinolines
  • Indoles
  • Ketoglutaric Acids
  • beta-Lactams
  • verruculogen
  • Heme
  • viridicatin
  • Tropolone
  • Iron
  • Oxygenases