Abstract
Covering: up to 2018 Non-heme iron enzymes are a versatile family of oxygenases that catalyze remarkable types of chemistry. This review highlights the intriguing chemistry of non-heme iron enzymes, especially those utilizing α-ketoglutarate (α-KG) as a co-substrate, in fungal secondary metabolism and aims to summarize how nature diversifies and complexifies natural products.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Catalysis
-
Ergot Alkaloids / biosynthesis
-
Fungal Proteins / chemistry*
-
Fungal Proteins / metabolism
-
Heme
-
Hydroxyquinolines / metabolism
-
Indoles / metabolism
-
Iron
-
Ketoglutaric Acids / metabolism
-
Oxygenases / chemistry*
-
Oxygenases / metabolism*
-
Tropolone / metabolism
-
beta-Lactams / metabolism
Substances
-
Ergot Alkaloids
-
Fungal Proteins
-
Hydroxyquinolines
-
Indoles
-
Ketoglutaric Acids
-
beta-Lactams
-
verruculogen
-
Heme
-
viridicatin
-
Tropolone
-
Iron
-
Oxygenases