Why do open-label placebos work? A randomized controlled trial of an open-label placebo induction with and without extended information about the placebo effect in allergic rhinitis

PLoS One. 2018 Mar 7;13(3):e0192758. doi: 10.1371/journal.pone.0192758. eCollection 2018.

Abstract

Background: Several studies demonstrated that placebo treatment may have a significant impact on many different symptoms. While in the traditional view concealment of the placebo is essential, recent studies report intriguing evidence that placebos may work even without deception. For example, it has been demonstrated that open-label placebos can improve symptoms in allergic rhinitis. However, the mechanisms of how placebos without concealment work remain unknown.

Trial design: In order to examine expectancy effects we conducted a randomized controlled trial (N = 46), in which patients with allergic symptoms received either placebos without deception or no pills at all. In half of those patients we induced positive expectations about the placebo effect. After two weeks we tested whether symptoms and quality of life had changed.

Results: Results revealed that open-label placebos improved allergic symptoms more than the control group. Inducing positive expectations had no effects on the improvement of allergic symptoms (the primary and more objective outcome), but on mental sum scores of the quality of life questionnaire.

Conclusions: Placebos without deception can improve symptoms in allergic rhinitis. Positive expectations do not contribute to the efficacy of open-label placebos, but seem to have an effect on more global and subjective well-being (mental or emotional quality of life).

Clinical trial registration number: German Clinical Trials Register, DRKS00012303.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Anti-Allergic Agents / therapeutic use
  • Cetirizine / therapeutic use*
  • Female
  • Humans
  • Loratadine / therapeutic use*
  • Male
  • Placebo Effect*
  • Placebos
  • Quality of Life
  • Rhinitis, Allergic / drug therapy*
  • Surveys and Questionnaires
  • Treatment Outcome
  • Young Adult

Substances

  • Anti-Allergic Agents
  • Placebos
  • Loratadine
  • Cetirizine

Grants and funding

The authors received no specific funding for this work.