Histologic and Radiographic Analysis of Nonhealing Extraction Sockets Treated with Bio-Oss Collagen After a 4-Month Healing Period: A Prospective Descriptive Study in Humans

Int J Periodontics Restorative Dent. July/August 2019;39(4):561–568. doi: 10.11607/prd.3152. Epub 2018 Mar 7.


Healing of extraction sockets may sometimes result in formation of fibrous tissue instead of bone, even after 4 months, an occurrence that may hinder implant placement. The aim of this preliminary observational study was to histologically evaluate quality and amount of bone regeneration after treating nonhealing sockets with a bovine-derived xenograft enriched with porcine collagen (Bio-Oss Collagen, Geistlich) without barrier membranes. Biopsy specimens were collected during implant placement, 4 months after grafting. A total of 10 cases were treated and evaluated. In all cases, correct implant placement was possible and no implant failure occurred up to 6 months after loading. The histologic analysis demonstrated new bone formation in all specimens. The percentage of newly formed bone was 29.1% (SD 20.71%; range 5% to 48%). Xenograft particles in direct contact with newly formed bone were visible, and mature lamellar bone was observed in 8 cases.

Publication types

  • Observational Study

MeSH terms

  • Alveolar Ridge Augmentation*
  • Animals
  • Bone Regeneration
  • Bone Substitutes*
  • Cattle
  • Collagen
  • Humans
  • Minerals
  • Prospective Studies
  • Tooth Extraction
  • Tooth Socket


  • Bio-Oss
  • Bone Substitutes
  • Minerals
  • Collagen