Structure and biosynthesis of mayamycin B, a new polyketide with antibacterial activity from Streptomyces sp. 120454

Sheng Tao Bo; Zi Fei Xu; Li Yang; Ping Cheng; Ren Xiang Tan; Rui Hua Jiao; Hui Ming Ge

doi:10.1038/s41429-018-0039-x

Structure and biosynthesis of mayamycin B, a new polyketide with antibacterial activity from Streptomyces sp. 120454

J Antibiot (Tokyo). 2018 Jun;71(6):601-605. doi: 10.1038/s41429-018-0039-x. Epub 2018 Mar 7.

Authors

Sheng Tao Bo¹, Zi Fei Xu¹, Li Yang¹, Ping Cheng¹, Ren Xiang Tan¹, Rui Hua Jiao², Hui Ming Ge³

Affiliations

¹ State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, School of Life Sciences, Nanjing University, Nanjing, 210023, China.
² State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, School of Life Sciences, Nanjing University, Nanjing, 210023, China. rhjiao@nju.edu.cn.
³ State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, School of Life Sciences, Nanjing University, Nanjing, 210023, China. hmge@nju.edu.cn.

PMID: 29515228
DOI: 10.1038/s41429-018-0039-x

Abstract

Mayamycin B, a new antibacterial type II polyketide, together with its known congener mayamycin A, were isolated from Streptomyces sp. 120454. The structure of new compound was elucidated by extensive spectroscopic analysis and comparison with literature data. Sequencing and bioinformatics analysis revealed the biosynthetic gene cluster for mayamycins A and B.

MeSH terms

Anti-Bacterial Agents / biosynthesis
Anti-Bacterial Agents / chemical synthesis*
Anti-Bacterial Agents / pharmacology*
Computational Biology
Genes, Bacterial / genetics
Magnetic Resonance Spectroscopy
Polyketide Synthases
Polyketides / chemical synthesis*
Polyketides / pharmacology*
Streptomyces / chemistry
Streptomyces / genetics
Streptomyces / metabolism*

Substances

Anti-Bacterial Agents
Polyketides
Polyketide Synthases