Fibrous Dysplasia of the Rib Mimicking a Malignant Bone Tumor at SPECT/CT with 99mTc-MDP

Clin Nucl Med. 2018 May;43(5):346-348. doi: 10.1097/RLU.0000000000002015.


We herein report a case of a 43-year-old man with a right 8th-rib bone tumor exhibiting features of malignancy at CT-scan. Considering that a SPECT/CT with Tc-MDP showed solitary intense radio-tracer uptake and the inconclusive results from a fine-needle biopsy, surgical en bloc tumor resection was performed. Pathologic analysis revealed a well-limited benign bone lesion ("fibrous rib dysplasia") composed by a cellular fibrous proliferation. Since benign osseous diseases may present an intense scintigraphic tracer uptake (as in this case), we suggest a certain caution when interpreting the results of SPECT/CT with Tc-MDP in order to avoid misdiagnosis and wrong treatments.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Bone Neoplasms / diagnostic imaging*
  • Diagnosis, Differential
  • Fibrous Dysplasia of Bone / diagnostic imaging*
  • Humans
  • Male
  • Radiopharmaceuticals
  • Ribs / diagnostic imaging
  • Ribs / pathology
  • Single Photon Emission Computed Tomography Computed Tomography*
  • Technetium Tc 99m Medronate


  • Radiopharmaceuticals
  • Technetium Tc 99m Medronate