Spectrum of Restrictive and Infiltrative Cardiomyopathies: Part 2 of a 2-Part Series

J Am Coll Cardiol. 2018 Mar 13;71(10):1149-1166. doi: 10.1016/j.jacc.2018.01.017.


Restrictive cardiomyopathies are the least common form of heart muscle disease. They are characterized as infiltrative and noninfiltrative, storage diseases, and endomyocardial disorders. Genetic diseases commonly present during childhood or adolescence. However, a growing percentage of elderly patients with heart failure with preserved ejection fraction are being recognized as having forms of restrictive cardiomyopathy, particularly cardiac amyloidosis. Noninvasive evaluation has replaced endomyocardial biopsy in the diagnostic evaluation of most suspected etiologies. The detection of infiltrative cardiomyopathies, particularly primary and secondary forms of iron overload, as well as inflammatory diseases such as sarcoidosis has slowly led to improved outcomes via disease-specific therapies.

Keywords: heart failure; restrictive cardiomyopathy; sarcoidosis.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Cardiomyopathy, Restrictive* / diagnosis
  • Cardiomyopathy, Restrictive* / etiology
  • Cardiomyopathy, Restrictive* / physiopathology
  • Disease Management*
  • Humans
  • Myocardium / pathology
  • Sarcoidosis / diagnosis