Hypoxia, Hypoxia-Inducible Factor-1α, and Innate Antileishmanial Immune Responses

Front Immunol. 2018 Feb 22:9:216. doi: 10.3389/fimmu.2018.00216. eCollection 2018.

Abstract

Low oxygen environments and accumulation of hypoxia-inducible factors (HIFs) are features of infected and inflamed tissues. Here, we summarize our current knowledge on oxygen levels found in Leishmania-infected tissues and discuss which mechanisms potentially contribute to local tissue oxygenation in leishmanial lesions. Moreover, we review the role of hypoxia and HIF-1 on innate antileishmanial immune responses.

Keywords: Nos2; hypoxia; hypoxia-inducible factor 1; leishmaniasis; macrophages; oxygen.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Hypoxia / immunology
  • Disease Models, Animal
  • Host-Parasite Interactions / immunology*
  • Humans
  • Hypoxia-Inducible Factor 1, alpha Subunit / immunology*
  • Immunity, Innate*
  • Leishmania / immunology*
  • Leishmania / pathogenicity
  • Leishmaniasis / immunology*
  • Leishmaniasis / parasitology
  • Myeloid Cells / immunology

Substances

  • Hypoxia-Inducible Factor 1, alpha Subunit