Application and Impact of Run-In Studies for the Evaluation of Statin Efficacy and Safety

J Gen Intern Med. 2018 Jun;33(6):792-794. doi: 10.1007/s11606-018-4349-2.

Michael Fralick^{1

2

3}, Jerry Avorn^{4

5}, Jessica M Franklin^{4

5}, Emily Bartsch⁵, Abdurrahman Abdurrob⁵, Aaron S Kesselheim^{4

5}

¹ Program on Regulation, Therapeutics, and Law (PORTAL), Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. mif823@mail.harvard.edu.
² Eliot Phillipson Clinician-Scientist Training Program, Toronto, Canada. mif823@mail.harvard.edu.
³ Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. mif823@mail.harvard.edu.
⁴ Program on Regulation, Therapeutics, and Law (PORTAL), Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
⁵ Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

No abstract available

Keywords: clinical trial; run-in; statin; study design.

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