The Past and Future Biology of the Human Microbiome in an Age of Extinctions

Cell. 2018 Mar 8;172(6):1173-1177. doi: 10.1016/j.cell.2018.02.040.


The evolutionary fate of humans is intimately linked with that of our microbiome. Medical and technological advances have caused large-scale changes in the composition and maturation of human-associated microbial communities, increasing our susceptibility to infectious and developmental diseases. Restoration of the human microbiome must become a priority for biomedicine.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents / administration & dosage
  • Biology / methods*
  • Biology / trends
  • Drug Resistance, Bacterial / genetics
  • Gastrointestinal Tract / embryology
  • Gastrointestinal Tract / growth & development
  • Gastrointestinal Tract / microbiology*
  • Genetic Variation
  • Host Microbial Interactions*
  • Humans
  • Metagenome / genetics*
  • Microbiota / physiology*


  • Anti-Bacterial Agents