Nitrate-rich dietary supplementation during pregnancy: The pros and cons

Abstract

Inorganic nitrate (NO₃) due to its potential endogenous conversion to nitric oxide (NO), is suggested as a compensatory fuel for disrupted NO pathways in the case of pathological stats during pregnancy. Dietary NO₃-rich supplement in the NO-deficient pregnant women is now suggested as a more appealing choice with fewer off-target effects which can attenuate hypertension and preeclampsia, improve placental blood flow and subsequently enhance maternal and neonatal health. There is also an increasing public interest and common health claims regarding beneficial effects of NO₃-rich dietary supplements like beetroot byproducts in pregnant women. Conversely, NO₃-rich dietary supplementation during pregnancy may be accompanied with a wide range of unexpected maternal and fatal adverse outcomes such as methemoglobinemia, alteration in embryonic cells and malignant transformation, as well as thyroid disorders. In conclusion, use of dietary inorganic NO₃ as a common supplement during pregnancy is currently on a long way from bench to bedside.

Keywords: Beetroot; Hypertension; Nitrate; Nitric oxide; Preeclampsia; Pregnancy.