Endometriosis, endometrioma, and ART results: Current understanding and recommended practices

Best Pract Res Clin Obstet Gynaecol. 2018 Aug:51:34-40. doi: 10.1016/j.bpobgyn.2018.01.019. Epub 2018 Feb 15.


Endometriosis and infertility are linked in a complex relationship, and a number of different pathogenetic mechanisms may associate the two. Endometriosis is diagnosed in 6-8% of women undergoing ART. Women with endometriosis appear to have similar ART outcomes compared to controls in terms of live birth rates, despite a lower oocyte quality. Laparoscopy should not be routinely performed before ART with the only aim to diagnose mild or moderate endometriosis, but if the latter is found, surgical removal can be considered, as it might improve pregnancy rates. In case of more severe forms of the disease (endometrioma and deep infiltrating endometriosis), the benefits of surgery before ART are uncertain and must be balanced against risks. Management decisions should be individualized based on patient choice, age, associated symptoms, and the risk of repeat surgery.

Keywords: Cystectomy; Gonadotropins; ICSI; Laparoscopy; Number of retrieved oocytes; Pregnancy rate.

Publication types

  • Review

MeSH terms

  • Birth Rate*
  • Case-Control Studies
  • Endometriosis / classification
  • Endometriosis / complications*
  • Endometriosis / epidemiology
  • Endometriosis / surgery
  • Female
  • Humans
  • Infertility, Female / etiology*
  • Infertility, Female / therapy
  • Laparoscopy
  • Oocytes / physiology
  • Pregnancy
  • Pregnancy Outcome
  • Reproductive Techniques, Assisted*
  • Retrospective Studies
  • Severity of Illness Index