Treatment with medium chain fatty acids milk of CD36-deficient preschool children

Nutrition. 2018 Jun:50:45-48. doi: 10.1016/j.nut.2017.11.005. Epub 2017 Nov 29.


Objective: CD36 deficiency is characterized by limited cellular long chain fatty acid uptake in the skeletal and cardiac muscles and often causes energy crisis in these muscles. However, suitable treatment for CD36 deficiency remains to be established. The aim of this study was to evaluate the clinical and metabolic effects of medium chain triacylglycerols (MCTs) in two CD36-deficient preschool children who often developed fasting hypoglycemia and exercise-induced myalgia.

Methods: Fasting blood glucose, total ketone bodies, and free fatty acids were examined and compared for usual supper diets and for diets with replacement of one component with 2 g/kg of 9% MCT-containing milk (MCT milk). Changes in serum creatine kinase and alanine aminotransferase levels, resulting from replacement of glucose water intake with 1 g/kg of MCT milk and determined by using bicycle pedaling tasks, were examined and compared. Hypoglycemic and/or myalgia episodes in daily life were also investigated.

Results: Biochemically, participants' blood glucose and total ketone bodies levels after overnight fasting substantially increased after dietary suppers containing MCT milk. Increases in serum creatine kinase and alanine aminotransferase levels resulting from the bicycle pedaling task were suppressed by MCT milk. Hypoglycemia leading to unconsciousness and tachycardia before breakfast decreased after introduction of dietary suppers containing MCT milk. Occurrence of myalgia in the lower limbs also decreased after intakes of MCT milk before long and/or strenuous exercising.

Conclusion: Our results suggest that MCTs can prevent fasting hypoglycemia and exercise-induced myalgia in CD36-deficient young children.

Keywords: CD36 deficiency; Hypoglycemia; Medium chain triacylglycerols; Myalgia; Preschool children.

Publication types

  • Case Reports

MeSH terms

  • Alanine Transaminase / blood
  • Animals
  • Blood Glucose / analysis
  • Blood Platelet Disorders / blood
  • Blood Platelet Disorders / complications
  • Blood Platelet Disorders / diet therapy*
  • Child, Preschool
  • Creatine Kinase / blood
  • Dietary Fats / administration & dosage*
  • Exercise / physiology
  • Fasting / blood
  • Fatty Acids, Nonesterified / blood
  • Food, Fortified / analysis*
  • Genetic Diseases, Inborn / blood
  • Genetic Diseases, Inborn / complications
  • Genetic Diseases, Inborn / diet therapy*
  • Humans
  • Hypoglycemia / etiology
  • Hypoglycemia / prevention & control
  • Ketones / blood
  • Male
  • Milk / chemistry*
  • Myalgia / etiology
  • Myalgia / prevention & control
  • Treatment Outcome
  • Triglycerides / administration & dosage*


  • Blood Glucose
  • Dietary Fats
  • Fatty Acids, Nonesterified
  • Ketones
  • Triglycerides
  • Alanine Transaminase
  • Creatine Kinase

Supplementary concepts

  • Platelet Glycoprotein IV Deficiency