An Italian multicentre study on methylchloroisothiazolinone/methylisothiazolinone contact sensitivity: understanding the structure-activity relationship

Luca Stingeni; Leonardo Bianchi; Caterina Foti; Paolo Romita; Luigi Rigano; Katharina Hansel; MCI/MI SIDAPA network

doi:10.1111/cod.12935

An Italian multicentre study on methylchloroisothiazolinone/methylisothiazolinone contact sensitivity: understanding the structure-activity relationship

Contact Dermatitis. 2018 Apr;78(4):297-299. doi: 10.1111/cod.12935.

Authors

Luca Stingeni¹, Leonardo Bianchi¹, Caterina Foti², Paolo Romita², Luigi Rigano³, Katharina Hansel¹; MCI/MI SIDAPA network

Collaborators

MCI/MI SIDAPA network:
Silvia Mariel Ferrucci, Monica Corazza, Cataldo Patruno, Massimo Gola, Donatella Schena, Paolo Pigatto

Affiliations

¹ Clinical, Allergological and Venereological Dermatology Section, Department of Medicine, University of Perugia, 06129 Perugia, Italy.
² Department of Biomedical Science and Human Oncology, Dermatological Clinic, University of Bari, 70124 Bari, Italy.
³ R&D Department, Institute of Skin and Product Evaluation, 20125 Milan, Italy.

PMID: 29527728
DOI: 10.1111/cod.12935

No abstract available

Keywords: MCI/MI; MI; chemical structure; cross-reaction; impurity; methylchloroisothiazolinone; methylisothiazolinone; patch test; primary sensitizer; structure-activity relationship.

Publication types

Multicenter Study

MeSH terms

Adult
Cohort Studies
Dermatitis, Allergic Contact / diagnosis*
Dermatitis, Allergic Contact / etiology*
Female
Humans
Italy
Male
Middle Aged
Patch Tests / methods
Preservatives, Pharmaceutical / adverse effects*
Structure-Activity Relationship
Thiazoles / adverse effects
Thiazoles / chemistry*

Substances

Preservatives, Pharmaceutical
Thiazoles
2-methyl-4-isothiazolin-3-one
5-chloro-2-methyl-4-isothiazolin-3-one