Abstract
Glucagon-like peptide 2 (GLP-2) is a hormone that has been shown to stimulate intestinal growth and attenuate intestinal inflammation. Despite being efficacious in a variety of animal models of disease, its therapeutic potential is hampered by the short half-life in vivo. We now describe a highly potent, stapled long-acting GLP-2 analog, peptide 10, that has a more than 10-fold longer half-life than teduglutide and improved intestinotrophic and anti-inflammatory effects in mouse models of DSS-induced colitis.
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis
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Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Colitis / chemically induced
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Colitis / drug therapy*
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Cross-Linking Reagents
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Cyclic AMP / biosynthesis
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Dextran Sulfate
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Drug Design
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Female
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Gastrointestinal Agents / chemical synthesis
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Gastrointestinal Agents / pharmacokinetics
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Gastrointestinal Agents / pharmacology*
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Glucagon-Like Peptide 2 / chemical synthesis
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Glucagon-Like Peptide 2 / pharmacokinetics
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Glucagon-Like Peptide 2 / pharmacology*
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Half-Life
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Intestines / drug effects
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Mice
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Mice, Inbred C57BL
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Models, Molecular
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Molecular Conformation
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Peptides / pharmacokinetics
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Peptides / pharmacology
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Cross-Linking Reagents
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Gastrointestinal Agents
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Glucagon-Like Peptide 2
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Peptides
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teduglutide
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Dextran Sulfate
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Cyclic AMP