Circle of Willis Collateral Flow in Carotid Artery Occlusion Is Depicted by 4D-CTA

World Neurosurg. 2018 Jun:114:421-426.e1. doi: 10.1016/j.wneu.2018.02.189. Epub 2018 Mar 9.


Background: In case of carotid artery occlusion, the risk and extent of ischemic cerebral damage are highly dependent on the pathways of collateral flow including the anatomy of the circle of Willis. In this report, cases are presented to illustrate that 4-dimensional computed tomography angiography (4D-CTA) can be considered as a noninvasive alternative to digital subtraction angiography for the evaluation of circle of Willis collateral flow.

Case description: Five patients with unilateral internal carotid artery (ICA) occlusion underwent 4D-CTA for the evaluation of intracranial hemodynamics. Next to a visual evaluation of 4D-CTA, temporal information was visualized using a normalized color scale on the cerebral vasculature, which enabled quantification of the contrast bolus arrival time. In these patients, 4D-CTA demonstrated dominant middle cerebral artery blood supply on the side of ICA occlusion originating from either the contralateral ICA or posterior circulation via the communicating arteries.

Conclusions: Temporal dynamics of collateral flow in the circle of Willis can be depicted with 4D-CTA in patients with a unilateral carotid artery occlusion.

Keywords: 4D-CTA; Angiography; Brain; Stroke.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Carotid Artery Diseases / diagnostic imaging*
  • Carotid Artery Diseases / surgery
  • Carotid Artery, Internal / diagnostic imaging*
  • Carotid Artery, Internal / surgery*
  • Circle of Willis / diagnostic imaging*
  • Circle of Willis / surgery
  • Collateral Circulation / physiology*
  • Computed Tomography Angiography / methods*
  • Four-Dimensional Computed Tomography / methods*
  • Humans
  • Male
  • Middle Aged