Potent Activities of Luliconazole, Lanoconazole, and Eight Comparators against Molecularly Characterized Fusarium Species

Mahdi Abastabar; Abdullah M S Al-Hatmi; Mohammad Vafaei Moghaddam; G Sybren de Hoog; Iman Haghani; Seyed Reza Aghili; Tahereh Shokohi; Mohammad Taghi Hedayati; Roshanak Daie Ghazvini; Reza Kachuei; Ali Rezaei-Matehkolaei; Koichi Makimura; Jacques F Meis; Hamid Badali

doi:10.1128/AAC.00009-18

Potent Activities of Luliconazole, Lanoconazole, and Eight Comparators against Molecularly Characterized Fusarium Species

Antimicrob Agents Chemother. 2018 Apr 26;62(5):e00009-18. doi: 10.1128/AAC.00009-18. Print 2018 May.

Authors

Mahdi Abastabar¹, Abdullah M S Al-Hatmi^{2

3

4}, Mohammad Vafaei Moghaddam⁵, G Sybren de Hoog^{2

3}, Iman Haghani¹, Seyed Reza Aghili¹, Tahereh Shokohi¹, Mohammad Taghi Hedayati¹, Roshanak Daie Ghazvini⁶, Reza Kachuei⁷, Ali Rezaei-Matehkolaei⁸, Koichi Makimura^{9

10}, Jacques F Meis^{3

11}, Hamid Badali^{12

13}

Affiliations

¹ Invasive Fungi Research Center (IFRC), School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
² Westerdijk Fungal Biodiversity Institute, Utrecht, The Netherlands.
³ Centre of Expertise in Mycology Radboud University Medical Centre/Canisius Wilhelmina Hospital, Nijmegen, The Netherlands.
⁴ Ministry of Health, Directorate General of Health Services, Ibri, Oman.
⁵ Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.
⁶ Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
⁷ Molecular Biology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
⁸ Department of Medical Mycology, School of Medicine, Health Research Institute, Infectious and Tropical Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
⁹ Laboratory of Space and Environmental Medicine, Graduate School of Medicine, Teikyo University, Tokyo, Japan.
¹⁰ Teikyo University Institute of Medical Mycology, Tokyo, Japan.
¹¹ Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands.
¹² Invasive Fungi Research Center (IFRC), School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran badalii@yahoo.com.
¹³ Department of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Abstract

A collection of clinical (n = 47) and environmental (n = 79) Fusarium isolates were tested against 10 antifungal drugs, including 2 novel imidazoles. Luliconazole and lanoconazole demonstrated very low geometric mean MIC values of 0.005 and 0.013 μg/ml, respectively, compared with 0.51 μg/ml for micafungin, 0.85 μg/ml for efinaconazole, 1.12 μg/ml for natamycin, 1.18 μg/ml for anidulafungin, 1.31 μg/ml for voriconazole, 1.35 μg/ml for caspofungin, 1.9 μg/ml for amphotericin B, and 4.08 μg/ml for itraconazole. Results show that these drugs are potential candidates for (topical) treatment of skin and nail infections due to Fusarium species.

Keywords: Fusarium species; intrinsic resistance; lanoconazole; luliconazole.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antifungal Agents / pharmacology*
Caspofungin / pharmacology
Drug Resistance, Fungal / genetics
Echinocandins / pharmacology
Fusarium / drug effects*
Fusarium / genetics*
Imidazoles / pharmacology*
Itraconazole / pharmacology
Microbial Sensitivity Tests
Triazoles / pharmacology
Voriconazole / pharmacology

Substances

Antifungal Agents
Echinocandins
Imidazoles
Triazoles
Itraconazole
latoconazole
Caspofungin
efinaconazole
Voriconazole
luliconazole