CRISPR-Cas12a has both cis- and trans-cleavage activities on single-stranded DNA

Cell Res. 2018 Apr;28(4):491-493. doi: 10.1038/s41422-018-0022-x. Epub 2018 Mar 12.

Shi-Yuan Li^{1

2}, Qiu-Xiang Cheng³, Jia-Kun Liu^{1

2}, Xiao-Qun Nie^{1

2}, Guo-Ping Zhao^{1

4}, Jin Wang⁵

¹ Key Laboratory of Synthetic Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 200032, Shanghai, China.
² University of Chinese Academy of Sciences, 100049, Beijing, China.
³ Shanghai Tolo Biotechnology Company Limited, 200233, Shanghai, China. qxcheng@tolobio.com.
⁴ Department of Microbiology and Li KaShing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Shatin, New Territories, China.
⁵ Key Laboratory of Synthetic Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 200032, Shanghai, China. wangj01@hotmail.com.

No abstract available

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