Proteolytic Remodeling of Perineuronal Nets: Effects on Synaptic Plasticity and Neuronal Population Dynamics

Neural Plast. 2018 Feb 4;2018:5735789. doi: 10.1155/2018/5735789. eCollection 2018.

Abstract

The perineuronal net (PNN) represents a lattice-like structure that is prominently expressed along the soma and proximal dendrites of parvalbumin- (PV-) positive interneurons in varied brain regions including the cortex and hippocampus. It is thus apposed to sites at which PV neurons receive synaptic input. Emerging evidence suggests that changes in PNN integrity may affect glutamatergic input to PV interneurons, a population that is critical for the expression of synchronous neuronal population discharges that occur with gamma oscillations and sharp-wave ripples. The present review is focused on the composition of PNNs, posttranslation modulation of PNN components by sulfation and proteolysis, PNN alterations in disease, and potential effects of PNN remodeling on neuronal plasticity at the single-cell and population level.

Publication types

  • Review

MeSH terms

  • Animals
  • Brain / metabolism*
  • Brain / pathology
  • Humans
  • Interneurons / metabolism
  • Interneurons / pathology
  • Nerve Net / metabolism*
  • Nerve Net / pathology
  • Nervous System Diseases / metabolism
  • Nervous System Diseases / pathology
  • Neuronal Plasticity / physiology*
  • Neurons / metabolism*
  • Neurons / pathology
  • Peripheral Nerves / metabolism
  • Peripheral Nerves / pathology
  • Proteolysis*