APC Moonlights to Prevent Wnt Signalosome Assembly

Dev Cell. 2018 Mar 12;44(5):535-537. doi: 10.1016/j.devcel.2018.02.018.


The scaffold protein APC has a well-known function in ensuring β-catenin destruction. In this issue of Developmental Cell, Saito-Diaz et al. (2018) uncover another role for APC in Wnt signaling: to prevent clathrin-dependent signalosome formation in the absence of ligand.

Publication types

  • Comment

MeSH terms

  • Wnt Signaling Pathway*
  • beta Catenin*


  • beta Catenin