APC Moonlights to Prevent Wnt Signalosome Assembly

Ian John McGough; Jean-Paul Vincent

doi:10.1016/j.devcel.2018.02.018

APC Moonlights to Prevent Wnt Signalosome Assembly

Dev Cell. 2018 Mar 12;44(5):535-537. doi: 10.1016/j.devcel.2018.02.018.

Authors

Ian John McGough¹, Jean-Paul Vincent²

Affiliations

¹ The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. Electronic address: ian.mcgough@crick.ac.uk.
² The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. Electronic address: jp.vincent@crick.ac.uk.

Abstract

The scaffold protein APC has a well-known function in ensuring β-catenin destruction. In this issue of Developmental Cell, Saito-Diaz et al. (2018) uncover another role for APC in Wnt signaling: to prevent clathrin-dependent signalosome formation in the absence of ligand.

Publication types

Comment

MeSH terms

Wnt Signaling Pathway*
beta Catenin*

Substances

beta Catenin