Delayed sleep phase syndrome and bipolar disorder: Pathogenesis and available common biomarkers

Sleep Med Rev. 2018 Oct;41:133-140. doi: 10.1016/j.smrv.2018.02.002. Epub 2018 Feb 13.


Circadian rhythm disturbances are common in bipolar affective disorder (BD). Delayed sleep-wake phase syndrome (DSWPD) is the most prevalent circadian rhythm sleep-wake disorder (CRSWDs) and is frequently observed in BD. It is unclear whether DSWPD in BD is an independent process or is a consequence of BD. In this hypothetical review, we discuss the overlap between BD and DSWPD and potential common biomarkers for DSWPD and BD. The review will include a discussion of the genetics of DSWPD and BD. Biomarkers elucidating the pathophysiological processes occurring in these two disorders may offer insight into the etiology and prognosis of both conditions.

Keywords: Biomarkers; Bipolar disorder; Circadian rhythm sleep-wake disorders; Delayed sleep wake phase disorder; Melatonin; Mood disorder; Sleep disorders.

Publication types

  • Review

MeSH terms

  • Biomarkers
  • Bipolar Disorder / complications*
  • Bipolar Disorder / physiopathology*
  • Humans
  • Sleep Disorders, Circadian Rhythm / etiology
  • Sleep Disorders, Circadian Rhythm / physiopathology*
  • Sleep Disorders, Circadian Rhythm / psychology


  • Biomarkers