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, 8 (1), 4411

Macular Choroidal Small-Vessel Layer, Sattler's Layer and Haller's Layer Thicknesses: The Beijing Eye Study

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Macular Choroidal Small-Vessel Layer, Sattler's Layer and Haller's Layer Thicknesses: The Beijing Eye Study

Jing Zhao et al. Sci Rep.

Abstract

To study macular choroidal layer thickness, 3187 study participants from the population-based Beijing Eye Study underwent spectral-domain optical coherence tomography with enhanced depth imaging for thickness measurements of the macular small-vessel layer, including the choriocapillaris, medium-sized choroidal vessel layer (Sattler's layer) and large choroidal vessel layer (Haller's layer). In multivariate analysis, greater thickness of all three choroidal layers was associated (all P < 0.05) with higher prevalence of age-related macular degeneration (AMD) (except for geographic atrophy), while it was not significantly (all P > 0.05) associated with the prevalence of open-angle glaucoma or diabetic retinopathy. There was a tendency (0.07 > P > 0.02) toward thinner choroidal layers in chronic angle-closure glaucoma. The ratio of small-vessel layer thickness to total choroidal thickness increased (P < 0.001; multivariate analysis) with older age and longer axial length, while the ratios of Sattler's layer and Haller's layer thickness to total choroidal thickness decreased. A higher ratio of small-vessel layer thickness to total choroidal thickness was significantly associated with a lower prevalence of AMD (early type, intermediate type, late geographic type). Axial elongation-associated and aging-associated choroidal thinning affected Haller's and Sattler's layers more markedly than the small-vessel layer. Non-exudative and exudative AMD, except for geographic atrophy, was associated with slightly increased choroidal thickness.

Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Optical coherence tomographic horizontal image of the macula showing the assessment of the thickness of the large vessel layer (Haller’s layer, outer layer), the medium-sized vessel layer (Sattler’s layer; middle layer), and the remaining inner layer containing small vessels, including the choriocapillaris, in the foveal region and at 750 µm nasal and temporal to the foveola.
Figure 2
Figure 2
Graph showing the distribution of the ratio of subfoveal small-vessel layer thickness (including choriocapillaris) to total subfoveal choroidal thickness, stratified by age, in the Beijing Eye Study 2011 in eyes without glaucoma, age-related macular degeneration, diabetic retinopathy, retinal vein occlusions, polypoidal choroidal vasculopathy or central serous choroidopathy and with an axial length less than 26.5 mm.
Figure 3
Figure 3
Graph showing the distribution of the ratio of subfoveal small-vessel layer thickness (including choriocapillaris) to total subfoveal choroidal thickness, stratified by axial length, in the Beijing Eye Study 2011 in eyes without glaucoma, age-related macular degeneration, diabetic retinopathy, retinal vein occlusions, polypoidal choroidal vasculopathy or central serous choroidopathy and with an axial length less than 26.5 mm.
Figure 4
Figure 4
Graph showing the distribution of the ratio of thickness of the subfoveal medium-sized choroidal vessel layer (Sattler’s layer) to total subfoveal choroidal thickness, stratified by age, in the Beijing Eye Study 2011 in eyes without glaucoma, age-related macular degeneration, diabetic retinopathy, retinal vein occlusions, polypoidal choroidal vasculopathy or central serous choroidopathy and with an axial length less than 26.5 mm.
Figure 5
Figure 5
Graph showing the distribution of the ratio of thickness of the subfoveal medium-sized choroidal vessel layer (Sattler’s layer) to total subfoveal choroidal thickness, stratified by axial length, in the Beijing Eye Study 2011 in eyes without glaucoma, age-related macular degeneration, diabetic retinopathy, retinal vein occlusions, polypoidal choroidal vasculopathy or central serous choroidopathy and with an axial length less than 26.5 mm.
Figure 6
Figure 6
Graph showing the distribution of the ratio of thickness of the subfoveal large choroidal vessel layer (Haller’s layer) to total subfoveal choroidal thickness, stratified by age, in the Beijing Eye Study 2011 in eyes without glaucoma, age-related macular degeneration, diabetic retinopathy, retinal vein occlusions, polypoidal choroidal vasculopathy or central serous choroidopathy and with an axial length less than 26.5 mm.
Figure 7
Figure 7
Graph showing the distribution of the ratio of thickness of the subfoveal large choroidal vessel layer (Haller’s layer) to total subfoveal choroidal thickness, stratified by axial length, in the Beijing Eye Study 2011 in eyes without glaucoma, age-related macular degeneration, diabetic retinopathy, retinal vein occlusions, polypoidal choroidal vasculopathy or central serous choroidopathy and with an axial length less than 26.5 mm.

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