A Belgian consensus protocol for autologous hematopoietic stem cell transplantation in multiple sclerosis

Acta Neurol Belg. 2018 Jun;118(2):161-168. doi: 10.1007/s13760-018-0905-0. Epub 2018 Mar 13.


Multiple sclerosis is considered to be an immune mediated inflammatory disorder of the central nervous system. It mainly affects young, socioeconomic active patients. Although our armamentarium for this disease has significantly evolved in recent years some patients remain refractory to conventional therapies. In these cases, autologous hematopoietic stem cell transplantation can be considered as a therapeutic option. Decreasing morbidity, mortality, and increasing patient awareness have led to rising inquiry by our patients about this treatment option. With the aim of a standardized protocol and data registration, a Belgian working party on stem cell therapy in multiple sclerosis was established. In this paper, we report the consensus protocol of this working party on autologous hematopoietic stem cell transplantation in multiple sclerosis.

Keywords: Autologous hematopoietic stem cell transplantation; Consensus Paper; Multiple sclerosis.

MeSH terms

  • Adolescent
  • Adult
  • Belgium / epidemiology
  • Consensus*
  • Disability Evaluation
  • Female
  • Hematopoietic Stem Cell Transplantation / methods*
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Multiple Sclerosis / diagnosis
  • Multiple Sclerosis / epidemiology
  • Multiple Sclerosis / surgery*
  • Registries
  • Transplantation, Autologous / methods
  • Treatment Outcome
  • Young Adult