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. 2018 May;12(5):439-446.
doi: 10.2217/bmm-2018-0020. Epub 2018 Mar 14.

Genome-wide Analysis of Nuclear Magnetic Resonance Metabolites Revealed Parent-Of-Origin Effect on Triglycerides in Medium Very Low-Density Lipoprotein in PTPRD Gene

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Genome-wide Analysis of Nuclear Magnetic Resonance Metabolites Revealed Parent-Of-Origin Effect on Triglycerides in Medium Very Low-Density Lipoprotein in PTPRD Gene

N Pervjakova et al. Biomark Med. .
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Abstract

Aim: The aim of the study was to explore the parent-of-origin effects (POEs) on a range of human nuclear magnetic resonance metabolites.

Materials & methods: We search for POEs in 14,815 unrelated individuals from Estonian and Finnish cohorts using POE method for the genotype data imputed with 1000 G reference panel and 82 nuclear magnetic resonance metabolites.

Results: Meta-analysis revealed the evidence of POE for the variant rs1412727 in PTPRD gene for the metabolite: triglycerides in medium very low-density lipoprotein. No POEs were detected for genetic variants that were previously known to have main effect on circulating metabolites.

Conclusion: We demonstrated possibility to detect POEs for human metabolites, but the POEs are weak, and therefore it is hard to detect those using currently available sample sizes.

Keywords: EGCUT; FINRISK; NMR metabolites; PTPRD; VLDL; parent-of-origin effects.

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