Anti-Obesity Effect of Red Radish Coral Sprout Extract by Inhibited Triglyceride Accumulation in a Microbial Evaluation System and in High-Fat Diet-Induced Obese Mice

J Microbiol Biotechnol. 2018 Mar 28;28(3):397-400. doi: 10.4014/jmb.1802.02005.

Abstract

Rhodosporidium toruloides, an oleaginous yeast, can be used as a fast and reliable evaluation tool to screen new natural lipid-lowering agents. Herein, we showed that triglyceride (TG) accumulation was inhibited by 42.6% in 0.1% red radish coral sprout extract (RRSE)-treated R. toruloides. We also evaluated the anti-obesity effect of the RRSE in a mouse model. The body weight gain of mice fed a high-fat diet (HFD) with 0.1% RRSE (HFD-RRSE) was significantly decreased by 60% compared with that mice fed the HFD alone after the 8-week experimental period. Body fat of the HFD-RRSE-fed group was dramatically reduced by 38.3% compared with that of the HFD-fed group.

Keywords: Rhodosporidium toruloides; anti-obesity; red radish coral sprout; triglyceride.

MeSH terms

  • Adipose Tissue
  • Animals
  • Anti-Obesity Agents / pharmacology*
  • Anti-Obesity Agents / therapeutic use
  • Body Weight / drug effects
  • Diet, High-Fat / adverse effects*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Obese
  • Models, Animal
  • Obesity / drug therapy*
  • Plant Extracts / pharmacology*
  • Raphanus / chemistry*
  • Rhodospirillum / drug effects
  • Triglycerides / metabolism*
  • Weight Gain / drug effects

Substances

  • Anti-Obesity Agents
  • Plant Extracts
  • Triglycerides