Ozone Disinfection of Home Nebulizers Effectively Kills Common Cystic Fibrosis Bacterial Pathogens

Pediatr Pulmonol. 2018 May;53(5):599-604. doi: 10.1002/ppul.23990. Epub 2018 Mar 15.


Objective: The Cystic Fibrosis Foundation (CFF) recommends routine nebulizer disinfection for patients but compliance is challenging due to the heavy burden of home care. SoClean® is a user friendly ozone based home disinfection device currently for home respiratory equipment. The objective of this study was to determine whether SoClean® has potential as a disinfection device for families with CF by killing CF associated bacteria without altering nebulizer output.

Hypothesis: Ozone based disinfection effectively kills bacterial pathogens inoculated to home nebulizer equipment without gross changes in nebulizer function.

Study design: Common bacterial pathogens associated with CF were inoculated onto the PariLC® jet nebulizer and bacterial recovery compared with or without varied ozone exposure. In separate experiments, nebulizer output was estimated after repeated ozone exposure by weighing the nebulizer.

Results: Ozone disinfection was time dependent with a 5 min infusion time and 120 min dwell time effectively killing >99.99% bacteria tested including Pseudomonas aeruginosa and Staphylococcus aureus. Over 250 h of repeat ozone exposure did not alter nebulizer output. This suggests SoClean® has potential as a user-friendly disinfection technique for home respiratory equipment.

Keywords: cystic fibrosis; infection control; nebulizer disinfection; ozone.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Load
  • Cystic Fibrosis / microbiology
  • Disinfectants*
  • Disinfection / instrumentation*
  • Disinfection / methods
  • Nebulizers and Vaporizers*
  • Ozone*


  • Disinfectants
  • Ozone