Abstract
Secretory carcinoma, originally described as mammary analog secretory carcinoma (MASC), is a low-grade salivary gland tumor characterized by a t(12;15)(p13;q25) translocation, resulting in an ETV6-NTRK3 gene fusion. Most MASCs are localized to the parotid gland and intraoral minor salivary glands. Moreover, ETV6-rearranged carcinomas with secretory features have been reported recently in the thyroid (with and without a history of radiation exposure), skin, and in very rare instances in the sinonasal tract. Here, we describe 2 cases of primary MASC in the sinonasal tract and provide a detailed clinical and histopathologic characterization of their morphology, immunohistochemical profile, and genetic background and highlight features allowing for its separation from its recently described molecular mimicker, ETV6-rearranged low-grade sinonasal adenocarcinoma.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenocarcinoma / chemistry
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Adenocarcinoma / genetics
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Adenocarcinoma / pathology*
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Aged
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Biomarkers, Tumor / analysis
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Biomarkers, Tumor / genetics
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Biopsy
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Diagnosis, Differential
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Female
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High-Throughput Nucleotide Sequencing
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Humans
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Immunohistochemistry
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In Situ Hybridization, Fluorescence
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Mammary Analogue Secretory Carcinoma / chemistry
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Mammary Analogue Secretory Carcinoma / genetics
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Mammary Analogue Secretory Carcinoma / pathology*
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Mammary Analogue Secretory Carcinoma / surgery
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Middle Aged
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Nasal Cavity / chemistry
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Nasal Cavity / pathology*
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Nasal Cavity / surgery
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Neoplasm Grading
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Nose Neoplasms / chemistry
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Nose Neoplasms / genetics
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Nose Neoplasms / pathology*
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Nose Neoplasms / surgery
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Oncogene Proteins, Fusion / genetics
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Predictive Value of Tests
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Registries
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Reverse Transcriptase Polymerase Chain Reaction
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Tomography, X-Ray Computed
Substances
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Biomarkers, Tumor
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ETV6-NTRK3 fusion protein, human
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Oncogene Proteins, Fusion