Uptake of human papillomavirus (HPV) vaccination in Hong Kong: Facilitators and barriers among adolescent girls and their parents

PLoS One. 2018 Mar 15;13(3):e0194159. doi: 10.1371/journal.pone.0194159. eCollection 2018.

Abstract

The present study is aimed at assessing the feasibility of delivering the HPV (human papillomavirus) vaccine to girls through a school-based program in Hong Kong, as well as to examine the facilitators and barriers associated with their participation. We approached 1,229 eligible girls aged 9 to 14 at eight schools in Hong Kong to join the program and then delivered the bivalent HPV vaccine at 0 and 6 months over the course of one school year. The students and their parents completed separate questionnaires to indicate their decision on whether or not to participate, and to assess their knowledge of cervical cancer and the HPV vaccine. The overall vaccine uptake was 81.4% (1,000/1,229) for the first dose and 80.8% (993/1,229) for the second dose. Parents and students were given separate questionnaires and asked whether or not they would like to participate in the vaccination program. 87.1% (1,010/1,160) of parents and 84.9% (974/1,147) of students indicated that they would join the program. The reasons associated with parents' decision not to vaccinate their daughters primarily included concerns around side effects and safety. Multivariate regression analysis showed that parents who thought that the vaccine would protect their daughter from getting cervical cancer (OR = 3.16, 95% CI = 1.39-7.15, p < .01), and those who reported having a doctor's recommendation (OR = 4.54, 95% CI = 1.05-19.57, p < .05) were more likely to join the program. In contrast, parents who had never heard of the vaccine (OR = .15, 95% CI = .03-.71, p < .02), those who were willing to pay more than HK$2,000 for the vaccine (OR = .39, 95% CI = .19-.81, p < .05), or had a preference to access it through a private clinic (OR = .44, 95% CI = .26-.75, p < .01) were significantly less likely to allow their daughter to join the program. Delivery of the HPV vaccine with high uptake rate in a school setting is feasible in Hong Kong. Engaging key stakeholders including school administrators, teachers and community physicians, and providing relevant information on safety and vaccine effectiveness to parents were important to the success of the program.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Child
  • Decision Making
  • Female
  • Health Knowledge, Attitudes, Practice
  • Hong Kong / epidemiology
  • Humans
  • Immunization Programs
  • Nuclear Family
  • Papillomavirus Infections / epidemiology
  • Papillomavirus Infections / prevention & control*
  • Papillomavirus Vaccines / therapeutic use*
  • Parents
  • Patient Acceptance of Health Care
  • Schools
  • Surveys and Questionnaires
  • Uterine Cervical Neoplasms / epidemiology
  • Uterine Cervical Neoplasms / prevention & control*
  • Vaccination

Substances

  • Papillomavirus Vaccines

Grants and funding

This research project was funded by Karen Leung Foundation (KLF) Limited (https://karenleungfoundation.org/). KLF is a non-for-profit registered charity in Hong Kong (IRD Ref No. 91/13069) that is focused on gynecological cancer prevention, care and treatment. The research project was a joint collaboration between the Karen Leung Foundation and the Chinese University of Hong Kong (CUHK). A grant was provided by the Karen Leung Foundation to Professor Albert Lee and Professor Paul Chan from the Chinese University of Hong Kong to develop the study design, educational materials, survey instruments, staffing, data collection and analysis. Decision to publish results from the study was a joint decision between the authors from the Chinese University of Hong Kong and the Karen Leung Foundation. Both parties took part in review and preparation of the paper.