The Molten Globule Concept: 45 Years Later

Biochemistry (Mosc). 2018 Jan;83(Suppl 1):S33-S47. doi: 10.1134/S0006297918140043.


In this review, we describe traditional systems where the molten globule (MG) state has been detected and give a brief description of the solution of Levinthal's paradox. We discuss new results obtained for MG-mediated folding of "nontraditional" proteins and a possible functional role of the MG. We also report new data on the MG, especially the dry molten globule.

Publication types

  • Historical Article
  • Review

MeSH terms

  • History, 20th Century
  • History, 21st Century
  • Protein Conformation
  • Protein Folding
  • Proteins / chemistry
  • Proteins / history*
  • Proteins / metabolism


  • Proteins