Newly Diagnosed Meniere's Disease: Clinical Course With Initiation of Noninvasive Treatment Including an Accounting of Vestibular Migraine

Ann Otol Rhinol Laryngol. 2018 May;127(5):331-337. doi: 10.1177/0003489418763224. Epub 2018 Mar 16.

Abstract

Objective: To describe the course of Meniere's disease with noninvasive treatment during the first few years after initial diagnosis.

Methods: A retrospective review of consecutive patients with newly diagnosed definite Meniere's disease between 2013 and 2016 and a minimum follow-up of 1 year. Patients received a written plan for low sodium, water therapy, and treatment with a diuretic and/or betahistine. Subjects were screened and treated for vestibular migraine as needed. Vertigo control and hearing status at most recent follow-up were assessed.

Results: Forty-four subjects had an average follow up of 24.3 months. Thirty-four percent had Meniere's disease and vestibular migraine, and 84% had unilateral Meniere's disease. Seventy-five percent had vertigo well controlled at most recent follow-up, with only noninvasive treatments. Age, gender, body mass index, presence of vestibular migraine, bilateral disease, and duration of follow-up did not predict noninvasive treatment failure. Worse hearing threshold at 250 Hz and lower pure tone average (PTA) at the time of diagnosis did predict failure. Fifty-two percent of ears had improved PTA at most recent visit, 20% had no change, and 28% were worse Conclusions: Encountering excellent vertigo control and stable hearing after a new diagnosis of Meniere's disease is possible with noninvasive treatments. Worse hearing status at diagnosis predicted treatment failure.

Keywords: Meniere’s disease; sensorineural hearing loss; vertigo; vestibular disorders; vestibular migraine.

MeSH terms

  • Audiometry, Pure-Tone
  • Auditory Threshold
  • Betahistine / therapeutic use
  • Dexamethasone / administration & dosage
  • Drug Combinations
  • Female
  • Follow-Up Studies
  • Glucocorticoids / administration & dosage
  • Hearing Loss, Sensorineural / complications
  • Humans
  • Hydrochlorothiazide / therapeutic use
  • Magnesium Oxide / therapeutic use
  • Male
  • Meniere Disease / complications
  • Meniere Disease / therapy*
  • Middle Aged
  • Middle Ear Ventilation
  • Migraine Disorders / complications
  • Migraine Disorders / drug therapy*
  • Retrospective Studies
  • Triamterene / therapeutic use
  • Vasodilator Agents / therapeutic use

Substances

  • Drug Combinations
  • Glucocorticoids
  • Vasodilator Agents
  • Hydrochlorothiazide
  • hydrochlorothiazide-triamterene
  • Magnesium Oxide
  • Dexamethasone
  • Triamterene
  • Betahistine