Extraskeletal presentation of Ewing's Sarcoma

P R Health Sci J. 2018 Mar;37(1):55-57.


The case of a 27-year-old Hispanic female who presented with an occipito-parietal tumor after suffering trauma to the area. A physical examination revealed no tenderness to palpation and with evidence of healing ulcerations. The biopsy was consistent with a synovial sarcoma. A wide excision of the mass (15cm x 14cm x 6cm) followed by a pericranial flap was performed. A follow-up CT showed recurrence involving the parietal sagittal sinus. After a second biopsy the mass was determined to be a small-cell sarcoma, consistent with Ewing's sarcoma. Chemotherapy included 8 cycles of doxorubicin, vincristine, and cyclophosphamide, with alternating cycles of etoposide and ifosfamide. A year later, a second wide excision of the mass was performed, followed by bilaminate skin substitute and skin graft placement for reconstruction of the soft-tissue defect. After chemotherapy, a follow-up PET scan showed no signs of re-uptake in any soft tissue or skeletal structures. After 2 years, the patient remains in complete remission.

Keywords: Oncology; Pathology; Primary Ewing’s Sarcoma; Reconstructive Surgery.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Female
  • Humans
  • Sarcoma, Ewing* / diagnosis
  • Sarcoma, Ewing* / therapy
  • Skull Neoplasms* / diagnosis
  • Skull Neoplasms* / therapy