Prevention of diabetic retinal capillary pericyte degeneration and loss by pancreatic islet allograft

Curr Eye Res. 1987 May;6(5):649-58. doi: 10.3109/02713688709034827.

Abstract

Degeneration and loss of retinal capillary pericytes are characteristic features of diabetic retinopathy. The effect of pancreatic islet cell allotransplantation across a major histocompatibility barrier on diabetic pericyte changes was examined in streptozotocin induced diabetic rats 14 months post-transplantation. Morphological studies of the retinal microvasculature were carried out using qualitative and quantitative morphological techniques. We describe significant prevention of pericyte degeneration and loss after successful allotransplantation suggesting that pancreatic islet allograft is a promising therapeutical approach in the prevention of diabetic retinopathy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Capillaries / pathology
  • Diabetes Mellitus, Experimental
  • Diabetic Retinopathy / prevention & control*
  • Endothelium / pathology
  • Islets of Langerhans Transplantation*
  • Male
  • Rats
  • Rats, Inbred Lew
  • Retinal Degeneration / prevention & control*
  • Retinal Vessels* / pathology
  • Streptozocin

Substances

  • Streptozocin