Drosophila position-specific antigens resemble the vertebrate fibronectin-receptor family

EMBO J. 1987 Apr;6(4):1037-43.

Abstract

The Drosophila position-specific (PS) antigens are a family of cell surface glycoprotein complexes thought to be involved in morphogenesis. Their overall structures and biochemical properties are similar to those of a group of vertebrate receptors, including those for fibronectin, fibrinogen and vitronectin, and also the leukocyte antigens Mac-1, LFA-1 and p150,95 and the VLA family of cell surface antigens. The N-terminal sequences of the alpha subunits of some of these molecules are homologous to the N-terminus of a PS antigen component. The Drosophila PS antigens thus appear to be homologous to these vertebrate receptors.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, Surface / genetics*
  • Cell Line
  • Chymotrypsin
  • Cyanogen Bromide
  • Drosophila melanogaster / genetics*
  • Fibronectins / analysis
  • Peptide Fragments / analysis
  • Receptors, Fibronectin
  • Receptors, Immunologic / genetics*
  • Sequence Homology, Nucleic Acid
  • Vertebrates

Substances

  • Antigens, Surface
  • Fibronectins
  • Peptide Fragments
  • Receptors, Fibronectin
  • Receptors, Immunologic
  • Chymotrypsin
  • Cyanogen Bromide