A Rare Case of Pediatric Vaginal Yolk Sac Tumor

Urology. 2018 Sep:119:137-139. doi: 10.1016/j.urology.2018.01.007. Epub 2018 Mar 13.


A 14-month-old girl was evaluated for intermittent vaginal bleeding. Vaginoscopy revealed a friable tumor, and biopsy results confirmed a yolk sac tumor. Alpha-fetoprotein was elevated (1386 ng/mL) at diagnosis but quickly normalized with chemotherapy. The patient remained tumor-free 12 months after diagnosis without the need for radical surgery. Although rare, malignant tumors of the vagina must be included in the differential diagnosis of prepubertal girls who present with vaginal bleeding. Primary yolk sac tumor of the vagina is seen in girls less than 3 years of age and is treated with chemotherapy with or without surgical excision. Prognosis is good with appropriate treatment.

Publication types

  • Case Reports

MeSH terms

  • Endodermal Sinus Tumor* / diagnosis
  • Endodermal Sinus Tumor* / drug therapy
  • Female
  • Humans
  • Infant
  • Vaginal Neoplasms* / diagnosis
  • Vaginal Neoplasms* / drug therapy