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. 2018 May;25(5):1002-1004.
doi: 10.1038/s41418-018-0093-8. Epub 2018 Mar 16.

How Do Thymic Epithelial Cells Die?

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Free PMC article

How Do Thymic Epithelial Cells Die?

Reema Jain et al. Cell Death Differ. .
Free PMC article

Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Loss of apoptosis, autophagy or necroptosis does not grossly alter thymic epithelial cell homeostasis. ac Overall numbers of TECs, TEC subsets, and AIRE+ or AIRE cells were determined by flow cytometry in mice with deletion of genes critical for autophagy (a), the death receptor pathway of apoptosis and necroptosis (b) or the intrinsic and death receptor pathways of apoptosis (c). TECs were classified into: mTEChigh (Ly51UEA-1+MHCIIhigh or Ly51MHCIIhigh), mTEClow (Ly51UEA-1+MHCIIlow or Ly51MHCIIlow), and cTECs (Ly51+UEA-1-MHCII+ or Ly51+MHCII+). “Controls” group in autophagy panel includes Atg7lox/lox and Foxn1+/+Atg7lox/+ mice (no difference observed between these groups). Data are representative for at least two independent experiments (except data for Atg5 which was a single experiment) with n ≥ 2/group. Graphical data (a) are pooled from two experiments for Atg7ΔFoxn1 only. Each point represents an individual mouse and graph bars indicate mean ± SEM. Groups were compared with a Student’s t-test (two sided, unpaired); *p < 0.05; **p < 0.01

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