Circulating bone morphogenetic protein-9 levels are associated with hypertension and insulin resistance in humans

Hong Huang; Wei Wang; Gangyi Yang; Yu Zhang; Xiaoqiang Li; Hua Liu; Lin Zhang; Hongting Zheng; Ling Li

doi:10.1016/j.jash.2018.02.007

Circulating bone morphogenetic protein-9 levels are associated with hypertension and insulin resistance in humans

J Am Soc Hypertens. 2018 May;12(5):372-380. doi: 10.1016/j.jash.2018.02.007. Epub 2018 Mar 1.

Authors

Hong Huang¹, Wei Wang², Gangyi Yang², Yu Zhang¹, Xiaoqiang Li³, Hua Liu⁴, Lin Zhang⁵, Hongting Zheng⁶, Ling Li⁷

Affiliations

¹ The Key Laboratory of Laboratory Medical Diagnostics in the Ministry of Education and Department of Clinical Biochemistry, College of Laboratory Medicine, Chongqing Medical University, Chongqing, China.
² Department of Endocrinology, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
³ Children's Hospital of Chongqing Medical University, Chongqing, China.
⁴ Department of Pediatrics, University of Mississippi Medical Center, Jackson, MS, USA.
⁵ Department of Endocrinology, the Ba Yan Nao Er Hospital, Inner Mongolia, China.
⁶ Department of Endocrinology, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
⁷ The Key Laboratory of Laboratory Medical Diagnostics in the Ministry of Education and Department of Clinical Biochemistry, College of Laboratory Medicine, Chongqing Medical University, Chongqing, China. Electronic address: liling31@hotmail.com.

PMID: 29550458
DOI: 10.1016/j.jash.2018.02.007

Abstract

It has been demonstrated that bone morphogenetic protein-9 (BMP-9) may have an important role in vascular development and stability. However, the association of circulating BMP-9 with essential hypertension (HTN) has not been established in humans. The objective of this study is to observe the changes of circulating BMP-9 levels in patients with HTN and to investigate the association of circulation BMP-9 and insulin resistance (IR) in a cross-sectional study. Two hundred twenty-five individuals, including 132 patients with hypertension, and 93 healthy controls, were included in the present study. Circulating BMP-9 concentrations were measured with an ELISA kit. The association of circulating BMP-9 with other parameters was analyzed. When compared with healthy subjects, circulating BMP-9 concentrations were markedly lower in HTN patients (46.20 [31.85-62.80] vs. 77.21 [39.33-189.15], P < .01) and correlated negatively with blood pressure and the homeostasis model assessment of insulin resistance (P < .05 or P < .01). Decreasing levels of BMP-9 were independently and markedly related to HTN. In a multiple linear regression analysis, only systolic blood pressure and free fatty acid concentrations were independently associated with circulating BMP-9. Our findings suggest that BMP-9 may be a serum biomarker for HTN and IR.

Keywords: Bone morphogenetic protein; cross-sectional study; hypertension; insulin resistance.

Associated data

ChiCTR/OCS-13003185