Influence of cardiovascular risk factors on longitudinal motion of the common carotid artery wall

Atherosclerosis. 2018 May;272:54-59. doi: 10.1016/j.atherosclerosis.2018.02.037. Epub 2018 Mar 2.

Abstract

Background and aims: Carotid artery longitudinal wall motion (CALM) is a new biomarker, which can be measured together with carotid intima-media thickness and distensibility measurements in the same session. Our objective was to study the relationship between these indicators of vascular health and cardiovascular risk factors in a large and well-characterized study population.

Methods: The study population consisted of 465 subjects aged 30-45 years. Successful measurements were performed in 287 participants.

Results: The peak-to-peak and retrograde amplitudes of the longitudinal motion were inversely correlated with systolic blood pressure (SBP; r = -0.152, p<0.05 and r = -0.189, p<0.01), diastolic blood pressure (DBP; r = -0.170, p<0.01 and r = -0.256, p<0.001) and body mass index (BMI; r = -0.158, p<0.01 and r = -0.291, p<0.001). In addition, retrograde amplitude of longitudinal motion indirectly correlated with total cholesterol and triglycerides (r = -0.163, p<0.01 and r = -0.228, p<0.001, respectively). Amplitude of antegrade longitudinal motion was directly correlated with DBP, total cholesterol, LDL-cholesterol, triglycerides and BMI (r = 0.198-0.274, p<0.001 for all). Antegrade longitudinal motion increased and retrograde longitudinal motion decreased with the increasing number of cardiovascular risk factors.

Conclusions: The magnitude of correlation coefficients between CALM parameters and risk factors was comparable with those for carotid intima-media thickness and distensibility. However, the correlation profile for various risk factors was different and CALM gives additional information regarding arteriosclerosis and risk factors.

Keywords: Arterial stiffness; Arteriosclerosis; Cardiovascular risk factors; Carotid artery distensibility; Intima-media thickness; Motion tracking; Ultrasound imaging.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Factors
  • Arteriosclerosis / physiopathology
  • Blood Pressure
  • Body Mass Index
  • Cardiovascular Diseases / epidemiology
  • Carotid Arteries / diagnostic imaging
  • Carotid Artery, Common / diagnostic imaging*
  • Carotid Artery, Common / pathology*
  • Carotid Intima-Media Thickness
  • Cross-Sectional Studies
  • Female
  • Finland
  • Follow-Up Studies
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Motion
  • Regional Blood Flow
  • Risk Factors
  • Ultrasonography