Antiviral Immune Response and the Route of Infection in Drosophila melanogaster

Adv Virus Res. 2018:100:247-278. doi: 10.1016/bs.aivir.2017.10.006. Epub 2017 Nov 21.


The use of Drosophila as a model organism has made an important contribution to our understanding of the function and regulation of innate immunity in insects. Indeed, insects can discriminate between different types of pathogens and mount specific and effective responses. Strikingly, the same pathogen can trigger a different immune response in the same organism, depending solely on the route of infection by which the pathogen is delivered. In this review, we recapitulate what is known about antiviral responses in Drosophila, and how they are triggered depending on the route and the mode used for the virus to infect its host.

Keywords: Antiviral immunity; Antiviral responses; Drosophila C virus; Drosophila melanogaster; Host–viral interactions; Insect control; Insects; Modes of infection; Viral tropism.

Publication types

  • Review

MeSH terms

  • Animals
  • Dicistroviridae / immunology
  • Dicistroviridae / physiology*
  • Disease Models, Animal
  • Drosophila Proteins / metabolism
  • Drosophila melanogaster / growth & development
  • Drosophila melanogaster / immunology*
  • Drosophila melanogaster / virology*
  • Host-Pathogen Interactions / immunology*
  • Immunity, Innate / immunology*
  • RNA Interference / immunology
  • Signal Transduction
  • Viral Tropism / immunology*


  • Drosophila Proteins

Supplementary concepts

  • Drosophila C virus