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. 2018 Jun;102:175-184.
doi: 10.1016/j.biopha.2018.03.057. Epub 2018 Mar 22.

Quercetin Attenuates Zymosan-Induced Arthritis in Mice

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Quercetin Attenuates Zymosan-Induced Arthritis in Mice

Carla F S Guazelli et al. Biomed Pharmacother. .

Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by articular lesions, recruitment of inflammatory cells and increased levels of pro-inflammatory cytokine. The intra-articular administration of zymosan is an experimental model that promotes inflammatory parameters resembling RA. Therefore, this model was used to investigate the efficacy of quercetin as a treatment of articular inflammation. Treatment with quercetin dose-dependently reduced zymosan-induced hyperalgesia, articular edema and the recruitment of neutrophils to the knee joint cavity. Histological analysis confirmed that quercetin inhibited zymosan-induced arthritis. The treatment with quercetin also inhibited zymosan-induced depletion of reduced glutathione (GSH) levels, TNFα and IL-1β production, and gp91phox, prepro-endothelin-1 (preproET-1), and cyclooxygenase-2 mRNA expression. These molecular effects of quercetin were related to the inhibition of the nuclear factor kappa-B and induction of Nuclear factor erythroid 2- related factor (Nrf2)/home oxygenase (HO-1) pathway. Thus, quercetin exerted anti-inflammatory, analgesic and antioxidant effects in experimental arthritis, suggesting quercetin is a possible candidate for arthritis treatment.

Keywords: Inflammation; NF-κB; Nrf2/heme Oxygenase (HO-1) pathway; Oxidative stress; Quercetin; Rheumatoid arthritis.

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