Simultaneous multiparametric PET/MRI for the assessment of therapeutic response to chemotherapy or concurrent chemoradiotherapy of cervical cancer patients: Preliminary results

Clin Imaging. 2018 May-Jun;49:163-168. doi: 10.1016/j.clinimag.2018.03.009. Epub 2018 Mar 13.

Abstract

Purpose: To assess the response to initial treatment strategies of cervical cancer using multiparametric-PET/MRI.

Material and methods: PET/MR-derived morphological (tumor size), functional (DWI, DCE-MRI) and metabolic (18F-FDG PET) parameters were acquired in pre- and posttreatment examinations of 8 patients. Besides RECIST- and PERCIST-criteria, functional quantitative parameters were used to assess therapeutic response.

Results: RECIST- and PERCIST-response criteria demonstrated high correlations for the differentiation between therapy-responders and non-responders, which was additionally reflected by functional (DWI, DCE-MRI) quantitative imaging parameters.

Conclusion: Multiparametric-PET/MRI bears the potential of a more comprehensive response assessment of initial treatment strategies in cervical cancer patients.

Keywords: Cervical cancer; Multiparametric analysis; PET/MRI; Therapy response assessment.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Cervix Uteri / pathology*
  • Chemoradiotherapy*
  • Female
  • Fluorodeoxyglucose F18
  • Humans
  • Magnetic Resonance Imaging / methods*
  • Middle Aged
  • Outcome Assessment, Health Care
  • Positron-Emission Tomography / methods*
  • Uterine Cervical Neoplasms* / diagnostic imaging
  • Uterine Cervical Neoplasms* / pathology
  • Uterine Cervical Neoplasms* / therapy

Substances

  • Fluorodeoxyglucose F18