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. 2018 Jun 1;30(2):142-146.
doi: 10.5792/ksrr.17.054.

Efficacy of Taurolidine Irrigation in Primary Total Knee Arthroplasty

Free PMC article

Efficacy of Taurolidine Irrigation in Primary Total Knee Arthroplasty

Young Ha Woo et al. Knee Surg Relat Res. .
Free PMC article


Purpose: Taurolidine is an antimicrobial agent that was originally used in the local treatment of peritonitis. The aim of this study was to evaluate the efficacy of taurolidine irrigation in primary total knee arthroplasty (TKA).

Materials and methods: All patients who underwent TKA at our institute from January 2015 to March 2017 were eligible. There were 300 patients in the taurolidine irrigation group and 300 patients in the control group. The patients in the taurolidine irrigation group were irrigated after implantation with a mix of 250 mL of taurolidine and 750 mL of normal saline. The patients in the control group were not irrigated after implantation. We compared postoperative C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and infection rate between groups.

Results: The taurolidine irrigation group had a significantly lower CRP (5.39 mg/dL vs. 7.55 mg/dL; p<0.001) and ESR (53.21 mm/hr vs. 58.74 mm/hr; p=0.003) on postoperative day 3 after TKA, as compared with the control group. However, there was no difference between the two groups on postoperative days 6, 13, and 20. Periprosthetic joint infection occurred in one patient in the taurolidine irrigation group.

Conclusions: We believe that it is not necessary to use taurolidine for patients who undergo primary TKA.

Keywords: Arthroplasty; C-reactive protein; Infection; Knee; Taurolidine.

Conflict of interest statement

Conflict of Interest

No potential conflict of interest relevant to this article was reported.


Fig. 1
Fig. 1
Consolidated Standards of Reporting Trials (CONSORT) flow diagram of patients. TKA: total knee arthroplasty.

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    1. Kurtz S, Ong K, Lau E, Mowat F, Halpern M. Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030. J Bone Joint Surg Am. 2007;89:780–5. - PubMed
    1. Daines BK, Dennis DA, Amann S. Infection prevention in total knee arthroplasty. J Am Acad Orthop Surg. 2015;23:356–64. doi: 10.5435/JAAOS-D-12-00170. - DOI - PubMed
    1. Kaptanoglu L, Kucuk HF, Colak E, Kurt N, Bingul SM, Akyol H, Torlak OA, Yazici F. The effect of taurolidine on experimental thrombus formation. Eur J Pharmacol. 2008;578:238–41. doi: 10.1016/j.ejphar.2007.08.035. - DOI - PubMed
    1. Traub WH, Leonhard B, Bauer D. Taurolidine: in vitro activity against multiple-antibiotic-resistant, nosocomially significant clinical isolates of Staphylococcus aureus, Enterococcus faecium, and diverse Enterobacteriaceae. Chemotherapy. 1993;39:322–30. doi: 10.1159/000239144. - DOI - PubMed
    1. Willatts SM, Radford S, Leitermann M. Effect of the anti-endotoxic agent, taurolidine, in the treatment of sepsis syndrome: a placebo-controlled, double-blind trial. Crit Care Med. 1995;23:1033–9. doi: 10.1097/00003246-199506000-00007. - DOI - PubMed

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