Brain-derived neutrophic factor in adolescents smoking waterpipe: The Irbid TRY

Mahmoud A Alomari; Nihaya A Al-Sheyab; Omar F Khabour; Karem H Alzoubi

doi:10.1016/j.ijdevneu.2018.03.007

Brain-derived neutrophic factor in adolescents smoking waterpipe: The Irbid TRY

Int J Dev Neurosci. 2018 Jun:67:14-18. doi: 10.1016/j.ijdevneu.2018.03.007. Epub 2018 Mar 16.

Authors

Mahmoud A Alomari¹, Nihaya A Al-Sheyab², Omar F Khabour³, Karem H Alzoubi⁴

Affiliations

¹ Division of Physical Therapy, Department of Rehabilitation Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, PO Box 3030, Irbid 22110, Jordan. Electronic address: Alomari@just.edu.jo.
² Faculty of Nursing, Maternal and Child Health Department, Jordan University of Science and Technology, Irbid, Jordan. Electronic address: nasheyab@just.edu.jo.
³ Department of Medical Laboratory Sciences, Jordan University of Science and Technology, Jordan. Electronic address: khabour@just.edu.jo.
⁴ Department of Clinical Pharmacy, Jordan University of Science and Technology, Irbid, Jordan. Electronic address: KHAlzoubi@just.edu.jo.

PMID: 29555563
DOI: 10.1016/j.ijdevneu.2018.03.007

Abstract

Background: Brain-derived neutrophic factor (BDNF) and tobacco consumption can affect many body functions and health. However, the relationship of BDNF with waterpipe (Wp) smoking is unknown. Therefore, the current study examined the relationship between Wp smoking and BDNF in adolescents.

Methods: Self-reported tobacco consumption and serum BDNF were determined in 195 waterpipe and 288 nonsmokers in 7th-10th grade students.

Results: Stepwise regression that included Wp smoking, gender, BMI, and location, showed that only Wp smoking (p < 0.0001) and gender (p < 0.0001) were related to serum BDNF. In addition, the ANCOVA found a main effect for Wp smoking (p < 0.0001) and gender (p < 0.0001) with lower BDNF in males smoking waterpipe.

Discussion: BDNF was diminished in adolescent Wp smokers, which might predispose adolescents for systematic adverse health and behavioral alterations. These results extend the negative health risks associated with cigarette smoking to that of water-pipe tobacco smoking.

Keywords: BDNF; Jordan; Students; Tobacco; Waterpipe smoking; Youth risk behavior survey.

MeSH terms

Adolescent
Adolescent Behavior / psychology*
Analysis of Variance
Brain-Derived Neurotrophic Factor / blood*
Cross-Sectional Studies
Female
Humans
Jordan / epidemiology
Longitudinal Studies
Male
Risk-Taking
Self Report
Smoking / blood*
Smoking / epidemiology*
Smoking Water Pipes* / statistics & numerical data
Statistics as Topic
Surveys and Questionnaires

Substances

Brain-Derived Neurotrophic Factor