Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
, 36 (1), 68-75

Inactivation of Enteroviruses by Ascorbic Acid and Sodium Bisulfite

Comparative Study

Inactivation of Enteroviruses by Ascorbic Acid and Sodium Bisulfite

R J Salo et al. Appl Environ Microbiol.

Abstract

Poliovirus type 1, coxsackievirus type A9, and echovirus type 7 were inactivated by sodium bisulfite and ascorbic acid. Inactivation rates depended upon concentration, temperature, and pH. RNA infectivity was lost during inactivation; the capsid was also altered by these inactivating agents, as determined by enzyme sensitivity assays and by tests of adsorption to cells. Structural modifications of the virus particles were not identical, suggesting that the mechanism of inactivation by ascorbic acid differs from that of sodium bisulfite.

Similar articles

See all similar articles

Cited by 6 articles

See all "Cited by" articles

References

    1. Nucleic Acids Res. 1976 Jan;3(1):261-76 - PubMed
    1. Arch Virol. 1976;52(4):269-82 - PubMed
    1. Bacteriol Rev. 1964 Mar;28:2-13 - PubMed
    1. Proc Soc Exp Biol Med. 1975 Apr;148(4):1237-43 - PubMed
    1. Virology. 1975 Feb;63(2):312-9 - PubMed

Publication types

LinkOut - more resources

Feedback