Efficient Multicomponent Active Template Synthesis of Catenanes

J Am Chem Soc. 2018 Apr 11;140(14):4787-4791. doi: 10.1021/jacs.8b01602. Epub 2018 Apr 2.

Abstract

We describe a simple and high yielding active template synthesis of [2]catenanes. In addition to mechanical bond formation using a single premacrocycle bearing an azide and alkyne moiety, our method is also suitable for the co-macrocyclization of readily available bis-alkyne and bis-azide comonomers and even short alkyne/azide components which oligomerize prior to mechanical bond formation.

Publication types

  • Research Support, Non-U.S. Gov't