To evaluate the clinical efficacy and safety of the innovative topical ozone therapy for infantile atopic dermatitis. Methods: Sixty children with atopic dermatitis were divided into a treatment group and a control group. The treatment group was showered with ozonated water (3-5 times a week) and smeared with ozonated oil (twice a day), while the control group was washed with warm running water and smeared with base oil, adding moisturizer if necessary. The treatment course was 2 weeks. Efficacy and side effect were evaluated. Results: The skin exudation was reduced and erosion was healing after 3-5 days topical ozone therapy for infantile atopic dermatitis. The effective rates were 80.0% and 20.0% in the treatment group and control group for 1 week, and 89.6% and 30.7% for 2 weeks, respectively, with significant difference between the 2 groups (P<0. 001). Conclusion: Innovative treatment of infantile atopic dermatitis with topical ozone application is safe and effective, which is worth popularizing in clinic.
目的：创新使用臭氧水和臭氧油外用治疗婴幼儿特应性皮炎，观察其临床疗效和安全性。方法：将60例婴幼儿特应性皮炎患者分为治疗组和对照组，治疗组用臭氧水洗浴每周3~5次，每次15 min，臭氧油外用每日2次，对照组用温水洗浴、基础油外用，疗程2周，两组患者必要时加用保湿霜，观察疗效和不良反应。结果：外用臭氧治疗婴幼儿特应性皮炎3~5 d后可见患儿皮损渗出减少、糜烂愈合。外用臭氧治疗组和对照组1周有效率分别为80.0%和20.0%，2周有效率分别为89.6%和30.7%，两组疗效比较差异有统计学意义(P<0.001)。两组患者在治疗过程中均未出现明显不良反应。结论：外用臭氧治疗婴幼儿特应性皮炎安全、有效，值得在临床推广应用。.