[Topical ozone application: An innovative therapy for infantile atopic dermatitis]

Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2018 Feb 28;43(2):163-167. doi: 10.11817/j.issn.1672-7347.2018.02.010.
[Article in Chinese]


To evaluate the clinical efficacy and safety of the innovative topical ozone therapy for infantile atopic dermatitis. Methods: Sixty children with atopic dermatitis were divided into a treatment group and a control group. The treatment group was showered with ozonated water (3-5 times a week) and smeared with ozonated oil (twice a day), while the control group was washed with warm running water and smeared with base oil, adding moisturizer if necessary. The treatment course was 2 weeks. Efficacy and side effect were evaluated. Results: The skin exudation was reduced and erosion was healing after 3-5 days topical ozone therapy for infantile atopic dermatitis. The effective rates were 80.0% and 20.0% in the treatment group and control group for 1 week, and 89.6% and 30.7% for 2 weeks, respectively, with significant difference between the 2 groups (P<0. 001). Conclusion: Innovative treatment of infantile atopic dermatitis with topical ozone application is safe and effective, which is worth popularizing in clinic.

目的:创新使用臭氧水和臭氧油外用治疗婴幼儿特应性皮炎,观察其临床疗效和安全性。方法:将60例婴幼儿特应性皮炎患者分为治疗组和对照组,治疗组用臭氧水洗浴每周3~5次,每次15 min,臭氧油外用每日2次,对照组用温水洗浴、基础油外用,疗程2周,两组患者必要时加用保湿霜,观察疗效和不良反应。结果:外用臭氧治疗婴幼儿特应性皮炎3~5 d后可见患儿皮损渗出减少、糜烂愈合。外用臭氧治疗组和对照组1周有效率分别为80.0%和20.0%,2周有效率分别为89.6%和30.7%,两组疗效比较差异有统计学意义(P<0.001)。两组患者在治疗过程中均未出现明显不良反应。结论:外用臭氧治疗婴幼儿特应性皮炎安全、有效,值得在临床推广应用。.

MeSH terms

  • Administration, Topical
  • Baths
  • Case-Control Studies
  • Dermatitis, Atopic / therapy*
  • Humans
  • Hydrotherapy / methods*
  • Infant
  • Oils / administration & dosage*
  • Ozone / administration & dosage*
  • Therapies, Investigational
  • Treatment Outcome


  • Oils
  • Ozone