The prognostic value of stress hyperglycaemia and previously unrecognized diabetes in acute stroke

Diabet Med. May-Jun 1987;4(3):237-40. doi: 10.1111/j.1464-5491.1987.tb00870.x.

Abstract

In a prospective study of 86 patients with acute stroke, blood glucose and HbA1 were estimated within 72 h of onset. The prevalence of previously diagnosed diabetes mellitus was 8% whereas 28% could be assumed to have had unrecognized hyperglycaemia preceeding the acute event as identified by a stable HbA1 raised more than two SD above the mean reference value. Complete functional recovery of the limbs within 4 weeks of the stroke was confined to those patients with a normal admission blood glucose. None of the patients with a raised admission blood glucose regained full functional recovery within 4 weeks. Cumulative mortality at 4 weeks was significantly raised in patients with an elevated blood glucose value irrespective of their HbA1 values (p less than 0.05). The prevalence of unrecognized hyperglycaemia as a risk factor for acute stroke is greater than previously reported in the UK and admission blood glucose concentration is of greatest importance in predicting early mortality and morbidity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Cerebrovascular Disorders / etiology*
  • Cerebrovascular Disorders / mortality
  • Diabetes Mellitus, Type 2 / complications*
  • Diabetic Angiopathies / etiology*
  • Female
  • Humans
  • Hyperglycemia / complications*
  • Male
  • Middle Aged
  • Prognosis
  • Risk
  • Stress, Physiological / complications*