Dynamic Neutron Scattering by Biological Systems

Annu Rev Biophys. 2018 May 20;47:335-354. doi: 10.1146/annurev-biophys-070317-033358. Epub 2018 Mar 21.

Abstract

Dynamic neutron scattering directly probes motions in biological systems on femtosecond to microsecond timescales. When combined with molecular dynamics simulation and normal mode analysis, detailed descriptions of the forms and frequencies of motions can be derived. We examine vibrations in proteins, the temperature dependence of protein motions, and concepts describing the rich variety of motions detectable using neutrons in biological systems at physiological temperatures. New techniques for deriving information on collective motions using coherent scattering are also reviewed.

Keywords: MD simulation; biomolecules; dynamics; neutron scattering.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Humans
  • Molecular Dynamics Simulation
  • Neutrons / therapeutic use*