A Review of Fabry Disease

Skin Therapy Lett. 2018 Mar;23(2):4-6.


Fabry disease (FD) is an X-linked lysosomal storage disease. A lack of alpha-galactosidase activity results in the accumulation of globotriaosylceramide in cells of various systems, leading to multi-systemic effects. The cutaneous hallmark of FD is a specific distribution of angiokeratoma. Other common symptoms include cornea verticillata, acroparesthesia, and sweating abnormalities. FD-specific symptoms, history, as well as examination of angiokeratoma can assist in the differential diagnosis. Enzyme replacement therapy is the current mainstay of treatment.

Keywords: enzyme replacement therapy; Fabry disease; alpha-galactosidase A; symptoms; treatment.

Publication types

  • Review

MeSH terms

  • Fabry Disease / diagnosis*
  • Fabry Disease / drug therapy
  • Fabry Disease / physiopathology
  • Humans
  • Randomized Controlled Trials as Topic