Mitochondria-ER Pas de Deux Controls Memory T Cell Function

Elizabeth M Steinert; Navdeep S Chandel

doi:10.1016/j.immuni.2018.03.002

Mitochondria-ER Pas de Deux Controls Memory T Cell Function

Immunity. 2018 Mar 20;48(3):479-481. doi: 10.1016/j.immuni.2018.03.002.

Authors

Elizabeth M Steinert¹, Navdeep S Chandel²

Affiliations

¹ Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
² Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address: nav@northwestern.edu.

PMID: 29562198
DOI: 10.1016/j.immuni.2018.03.002

Abstract

Memory CD8⁺ T cells mediate protective secondary immune responses. In this issue, Bantug et al. (2018) demonstrate that mTORC2-AKT-GSK3β signaling at mitochondria-ER contact sites enables the TCA cycle flux that is necessary for memory CD8⁺ T cells to produce IFN-γ.

Publication types

Comment

MeSH terms

CD8-Positive T-Lymphocytes*
Immunologic Memory
Interferon-gamma*
Mitochondria
Signal Transduction

Substances

Interferon-gamma

Grants and funding

P01 AG049665/AG/NIA NIH HHS/United States